Can an attenuated vaccine for coccidiosis in chickens increase profitability? Results on farms in Brazil

27 September, 2019

In Brazil, the use of vaccines to control coccidiosis in chickens is still uncommon, mainly because of a series of false beliefs or “myths” that spread over time. These false beliefs are mostly due to the experience that some companies have had in the past when using non-attenuated-type vaccines, thus severely injuring the intestinal wall, leading to a loss in performance.

Coccidiosis in chickens: In Brazil, the use of vaccines to control coccidiosis in chickens is still uncommon

The importance of controlling coccidiosis in chickens in Brasil is undeniable due to the great financial losses caused by the disease, either in its clinical or subclinical form.

Coccidiosis in chickens in Brasil: What’s the situation?

The subclinical disease causes numerous damages that may be imperceptible, given that they are often masked by other factors that occur on the farm. According to Doug Korver, in the 20th South Brazil Poultry Farming Symposium, besides the reduction in feed consumption, the bird experiences muscle degradation to compensate for the low absorption of amino acids due to intestinal injuries. Historically, coccidiosis in chickens has been controlled by most companies with the use of anticoccidial agents. However, it can be observed that the degree of resistance of field Eimeria spp. to most molecules is increasing, as well as drawbacks such as the use of Nicarbazin, which has a negative effect on the zootechnical results proportional to the dose used, including in some cases accompanied by slight losses, given that it interferes with the circulatory system, increasing cardiac output (Donzele et al. 2001). In Brazil, nowadays there are also vaccines for coccidiosis in chickens that contain all precocious attenuated Eimeria spp. strains. This allows replication to occur earlier and less intensely. Consequently, damage to the intestinal wall is minimal and does not result in a loss in performance. We are talking about coccidiosis vaccines like HIPRACOX®, which contains 5 precocious attenuated species of Eimeria spp. (E. acervulina, E.maxima, E. mitis, E. praecox and E. tenella), developed to be administered by spraying in the hatchery or upon arrival of the birds to the farm on the first day of life of the chicks. A good control method using vaccines for coccidiosis in chickens should offer both the options for continuous or rotational use. The rotation strategy is to alternate several consecutive vaccination cycles with anticoccidial cycles, because the vaccine strains are extremely sensitive, and after colonizing the farms with their oocysts, they make subsequent cycles with anticoccidials more effective, with better zootechnical and financial results. Over the last year some companies in Brazil decided to incorporate the vaccine for coccidiosis in chickens into their control programmes. These companies are generating a large volume of results under normal field conditions, which therefore represent the reality of Brazilian poultry farming.  

Results of the use of a vaccine for coccidiosis in chickens in Brazil: Company 1

The first company used Hipracox® and two more vaccines for coccidiosis in chickens made up of non-attenuated strains found on the Brazilian market for two consecutive cycles. Please find below the comparative table of feed conversions: Coccidiosis in chickens, Brasil: Evolution of the Feed Conversion throughout the vaccination cycles The adjusted feed conversion graph (3350 g) shows the evolution of each vaccine from cycle 1 to cycle 2, and Hipracox® was the vaccine that obtained the best overall feed conversion ratio (FCR) result and also the best FCR gain from one cycle to another. It is important to note that each company has its own nutritional level, always aiming for maximum performance at the lowest cost, which influences the FCR index. What is expected from a vaccine for coccidiosis in chickens is that with each vaccination cycle the zootechnical result improves as a result of the replacement of field resistant oocysts with drug-sensitive vaccine oocysts in the litter. The table below shows the capability each vaccine showed to improve feed conversion (3350 g adjusted) from cycle 1 to cycle 2. Coccidiosis in chickens: Capability of each vaccine showed to improve feed conversion from cycle 1 to cycle 2 It is important to point out the 42- grams improvement in FCR in the 2nd cycle with Hipracox®, in the same cycle vaccine B showed an improvement of only 7 grams and vaccine C resulted in a 15 grams reduction in FCR. Still, with regard to Feed Conversion Ratio, the table below compares Hipracox® with vaccines B and C, in cycle 1 and cycle 2. Coccidiosis in chickens: Feed conversion ratio of 2 vaccines Hipracox® in cycle 2 proved to be 53 grams better than vaccine C. Compared to vaccine B, Hipracox® outperformed it by 25 grams in the 1st cycle and 61 grams in the 2nd vaccination cycle. Coccidiosis in chickens: Better intestinal quality resulting in better feed conversion.
Picture: 2nd cycle vaccinated with Hipracox®. Better intestinal quality resulting in better feed conversion.
  The table below shows the comparison of mortality rates among the three vaccines for coccidiosis in chickens tested. Hipracox® showed the lowest mortalities and a clear evolution between cycles: Coccidiosis in chickens: Evolution of the mortality throughout the vaccination cycles The table below shows the comparison of Production Efficiency Factor (PEF) among the three vaccines for coccidiosis in chickens. Once again, the data showed that the flocks vaccinated with Hipracox® produced the best results: Coccidiosis in chickens: Evolution of the Production Efficiency Factor (PEF) throughout vaccination The PEF of the flocks vaccinated with Hipracox® was higher than those vaccinated with the vaccines B and C in both cycles.  

Results of the use of a vaccine for coccidiosis in chickens in Brazil: Company 2

In this other company, the initial objective was to control coccidiosis in chickens by rotating Hipracox® with anticoccidial agents. However, the results of the second vaccination cycle showed a lower production cost when compared to the anticoccidial programme used, and combined with the significant improvement in clinical cases of coccidiosis, the strategy adopted was to continue vaccinating with Hipracox®. It is important to point out that this company does not use antibiotic growth promoters (it is AGP-free). Coccidiosis in chickens: Evolution of the actual feed conversion The graph above shows the improvement in the actual feed conversion throughout the course of the vaccination cycles. As the field oocysts are replaced by Hipracox® oocysts, precocious attenuated, damage from wild-type strains can be avoided, and consequently, the bird performance is improved. Coccidiosis in chickens: Feed Convertion Rate through vaccinaton comparison In this company the gain provided by Hipracox® was 33 grams in the FCR in the 4th vaccinated cycle, compared to the FCR in the 1st cycle. All companies that used Hipracox® achieved a reduction in the number of treatments, mainly for enteritis. This result is the same as the one achieved by field observations in Belgium (Ronsmans et al., 2015). The graphs below show the results of the oocyst excretion curves on the post-vaccination days with Hipracox® vaccinated flocks, originating from a company with a high degree of resistance to anticoccidial agents. Coccidiosis in chickens: Oocysts per gram of faeces (OPG) Cycle 1 Coccidiosis in chickens: Oocysts per gram of faeces (OPG) Cycle 2 As it has already been pointed out by Dardi et al. in 2015, in the first vaccination cycle, the peak of excretion occurred at 28 days, but with an oocyst count far below what is deemed to be a challenge (60,000 oocysts/gram of faeces). In the second cycle, the count was also low, but the peak of excretion occurred at 21 days, that is, precocious and with low replication, which in other words means that it caused precocious immunity without prejudging outcomes.   Hipracox®, a live attenuated precocious vaccine against coccidiosis in chickens, already used for 12 years in Europe, succeeded in showing its potential in intensive poultry farming in Brazil, dispelling some false beliefs that spread over the years due to ignoring the technical and conceptual differences in vaccines (virulent – non-attenuated strains versus non-virulent – precocious attenuated strains). The use of coccidiosis vaccines for chickens, especially in the case of precocious attenuated vaccines, encourages sustainability in the production of broiler chickens, allowing to balance consumer market demand, animal health and economic viability for companies. BIBLIOGRAPHY:
  • Dardi M., Pagès M., Rubio J., Mathis G. F., De Gussem M., 2015. Anticoccidial Sensitivity test (AST) results from a farm vaccinated for three consecutive flocks with a coccidiosis vaccine. Proceedings of the XIX World Veterinary Poultry Association Congress. Cape Town, South Africa, 158.
  • Donzele J.l., Miranda de Oliveira R.F., Cella P.S., Rodrigues Oliveira-Neto A. 2001. Efeito da nicarbazina sobre o desempenho de frangos de corte recebendo diferentes níveis de lisina submetidos a estresse por calor. Rev. Bras. Zootec., vol.30, n.3, suppl.1, pp.1052-1057.
  • Korver D., 2019. Energetic Costs of coccidial infection and vaccination. 20º Simpósio Brasil Sul de Avicultura e 11º Brasil Sul Poultry Fair 02 a 04 de abril de 2019 – Chapecó, SC, – Brasil. Anais p. 97–100.

Related Posts

Library

Check latests documents

Calculator

Tools to prevent Eimeria

FAQ's

Facts you should know

Basic Personal Data Protection information:

Controller: LABORATORIOS HIPRA, S.A.
Purposes: Managing the contractual and/or business relationship with HIPRA, including sending news, promotions and invitations to events sponsored by HIPRA.
Lawful basis: Performance of the contractual relationship and HIPRA's legitimate Interest.
Recipients: Third parties to which HIPRA has entrusted cloud computing, security, auditing, mailing, technical and computer support services, as well as companies in its group.
Rights: Request access to and rectification or erasure of personal data and other rights as explained in the additional information. You can seeview the detailed additional information about data protection in our Privacy Policy.

For further information, please check our detailed information on Data Protection.
close-link

Website for veterinarians

The contents of this website are aimed exclusively at prescribing veterinarians. By clicking on ACCEPT you state that you are a veterinary professional. In other case, please contact a veterinarian and click on DECLINE.